Mazen Albaghdadi, MD

Mazen Albaghdadi, MD

Interventional Cardiology

Director of Cardiac
Catheterization Laboratory

Associate Program Director
Cardiology Fellowship at NCH​

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Research and clinical investigation, global health and cardiovascular training

About Dr. Albaghdadi

Dr. Albaghdadi received his medical degree from the University of Iowa Carver College of Medicine where he finished with a research distinction and was a member of the Alpha Omega Alpha Honors Society. After completing his residency in internal medicine at Northwestern University, Dr. Albaghdadi then simultaneously completed his cardiology fellowship, physician-scientist training program and masters of science in clinical investigation, all at Northwestern as well. He has since completed sub-specialty fellowships in interventional cardiology, vascular medicine and intervention at the Massachusetts General Hospital/Harvard Medical School where he was on the faculty. Dr. Albaghdadi then obtained additional training in structural and adult congenital interventions at the Toronto General Hospital/University of Toronto.

Dr. Albaghdadi is a highly decorated and well-published cardiologist and physician-scientist, with dozens of awards to his name. He has been published more than 50 times on a variety of medical topics. He is driven by research and clinical investigation. He is a champion of early-stage medical devices in interventional cardiology for patients where no therapies exist. In addition, Dr. Albaghdadi has an interest in global health and is an active volunteer and board member of a U.S.-based, non-profit that trains cardiovascular professionals in East Africa, known as Madaktari Africa.

Dr. Albaghdadi was born and raised in Clinton, Iowa. He is married to his high-school sweetheart, Elisa, and is the proud father of three children.


Rooney Heart Institute at NCH
399 9th Street North
Suite 300
Naples, FL 34102



• Northwestern University Graduate School
• University of Illinois at Chicago
• University of Iowa Carver College of Medicine


• Edwards Lifesciences in Partnership with the Cardiovascular Research Foundation
• Toronto General Hospital/University of Toronto
• Massachusetts General Hospital/Harvard Medical School
• Northwestern University Feinberg School of Medicine


• Cardiovascular Disease
• Interventional Cardiology
• Physician in Vascular Interpretation


1. Lino Cardenas CL, Aguilar Pineda JA, Albaghdadi M, Wanlin J, Vera Lopez KJ, Nieto Montesinos R, Alverez Fernandez KL, del Carpio GD, Gomez Valdez B, Linday ME, Malhotra R. Structural and Functional Analysis of Female Sex Hormones Against SARS-Cov-2 Cell Entry. Int. J. Mol. Sci. 2021 (accepted for publication October 15, 2021).

2. Osborn EA, Ughi GJ, Verjans JW, Piao Z, Gerbaud E, Albaghdadi M, Khraishah H, Kassab MB, Takx RAP, Cui J, Mauskapf A, Shen C, Yeh RW, Klimas MT, Tawakol A, Tearney GJ, Jaffer FA. Intravascular Molecular-Structural Assessment of Arterial Inflammation in Preclinical Atherosclerosis Progression. JACC Cardiovasc Imaging. 2021 Aug 11:S1936-878X(21)00507-6. doi: 10.1016/j.jcmg.2021.06.017. Epub ahead of print. PMID: 34419392.

3. Kellnberger S, Wissmeyer G, Albaghdadi M, Piao Z, Li W, Mauskapf A, Rauschendorfer P, Tearney GJ, Ntziachristos V, Jaffer FA. Intravascular molecular-structural imaging with a miniaturized integrated near-infrared fluorescence and ultrasound catheter. J Biophotonics. 2021 Jun 23:e202100048. doi: 10.1002/jbio.202100048. Epub ahead of print. PMID: 34164943.

4. Babaee S, Shi Y, Abbasalizadeh S, Tamang S, Hess K, Collins JE, Ishida K, Lopes A, Williams M, Albaghdadi M, Hayward AM, Traverso G. Kirigami-inspired stents for sustained local delivery of therapeutics. Nat Mater. 2021 Jun 14. doi: 10.1038/s41563-021-01031-1. Epub ahead of print. PMID: 34127823.

5. Adler A, Albaghdadi M, Siddiqui U, Bitton-Worm K, Rachelli N, Gordon U, Kuck KH. Detection of Leak From Left Atrial Appendage Occlusion Using Dielectric Imaging. IEEE Transactions on Biomedical Engineering, vol. 68, no. 7, pp. 2110-2116, July 2021, doi: 10.1109/TBME.2020.3025992.

6. Albaghdadi MS, Ikegami R, Kassab MB, Gardecki JA, Kunio M, Chowdhury MM, Khamis R, Libby P, Tearney GJ, Jaffer FA. Near-Infrared Autofluorescence in Atherosclerosis Associates With Ceroid and Is Generated by Oxidized Lipid-Induced Oxidative Stress. Arterioscler Thromb Vasc Biol. 2021 May 20:ATVBAHA120315612. doi: 10.1161/ATVBAHA.120.315612. Epub ahead of print. PMID: 34011166.

7. Albaghdadi MS, Young MN, Chowdhury MM, Assmann S, Hamza T, Siami S, Villarreal M, Strong M, Menard M, Farber A, Rosenfield K. Clinical practice patterns and ascertainment bias for cardiovascular events in a randomized trial: A survey of investigators in the BEST-CLI trial. Vasc Med. 2021 Apr;26(2):180-186. doi: 10.1177/1358863X21995897. PMID: 33825577.

8. Khraishah H, Alahmad B, Alfaddagh A, Jeong SY, Mathenge N, Kassab MB, Kolte D, Michos ED, Albaghdadi M. Sex disparities in the presentation, management and outcomes of patients with acute coronary syndrome: insights from the ACS QUIK trial. Open Heart. 2021 Jan;8(1):e001470. doi: 10.1136/openhrt-2020-001470. PMID: 33504633; PMCID: PMC7843306.

9. Elgendy IY, Kolte D, Mansour MK, Sakhuja R, Elmariah S, Jaffer FA, Neilan TG, Januzzi JL, Weinberg I, Albaghdadi MS. Incidence, Predictors, and Outcomes of Thrombotic Events in Hospitalized Patients With Viral Pneumonia. Am J Cardiol. 2021 Jan 13:S0002-9149(21)00027-8. doi: 10.1016/j.amjcard.2021.01.001. Epub ahead of print. PMID: 33453170; PMCID: PMC7807171.

10. Gurin MI, Beyer SE, Weinberg M, Parikh SA, Armstrong EJ, Albaghdadi MS, Aronow HD, Carroll BJ, Yeh R, Secemsky EA. Health Care Utilization Following Inpatient Femoropopliteal Revascularization With Drug-Coated Balloon Angioplasty: A Nationwide Cohort Analysis. J Endovasc Ther. 2021 Jan 11:1526602820984111. doi: 10.1177/1526602820984111. Epub ahead of print. PMID: 33426984.

11. Butala NM, Patel NK, Chhatwal J, Vahdat V, Pomerantsev EV, Albaghdadi M, Sakhuja R, Rosenzweig A, Elmariah S. Patient and Provider Risk in Managing ST-Elevation Myocardial Infarction During the COVID-19 Pandemic: A Decision Analysis. Circ Cardiovasc Interv. 2020 11; 13(11):e010027. PMID: 33167699.

12. Khraishah H, Alahmad B, Secemsky E, Young MN, ElGuindy A, Siedner MJ, Kassab M, Kolte D, Khanbhai K,Janabi M, Kennedy K, Albaghdadi MS. Comparative Effectiveness of Reperfusion Strategies in Patients with ST-Segment Elevation Myocardial Infarction: A Secondary Analysis of the Acute Coronary Syndrome Quality Improvement in Kerala (ACS QUIK) Trial. Global Heart. 2020;15(1):68. DOI:

13. Adler A, Albaghdadi M, Siddiqqui U, Bitton Worms K, Gordon U, Rachelli N, Kuck KH. Detection of Leak from Left Atrial Appendage Occlusion using Dielectric Imaging.IEEE Transactions on Biomedical Engineering. 2020 Sep 22; PP. doi: 10.1109/TBME.2020.3025992. Online ahead of print.

14. Albaghdadi M, Kadlec A, Adler A, Siddiqui U, Romanov A, Kuck KH, Sievert H, Leon, Vahl T. Peri-Device Leaks after Percutaneous Left Atrial Appendage Closure: Clinical Significance and Unmet Diagnostic Needs. Structural Heart. Online Sept 02, 2020.

15. Eslami P, Hartman EMJ, Albaghdadi M, Karady J, Jin Z, Thondapu V, Cefalo NV, Lu MT, Coksun A, Stone PH, Marsden A, Hoffman U, Wentzel JJ. Validation of Wall Shear Stress Assessment in Non-invasive Coronary CTA versus Invasive Imaging: A Patient-specific Computational Study. Annals of Biomedical Engineering (in-press). September 2020.

16. Tzafriri AR, Muraj B, Garcia-Polite F, Salazar-Martín AG, Markham P, Zani B, Spognardi A, Albaghdadi M, Alston S, Edelman ER. Balloon-based drug coating delivery to the artery wall is dictated by coating micro-morphology and angioplasty pressure gradients. Biomaterials. 2020 November, Volume 260, 120337.

17. Eslami P, Thondapu V, Karady J, Hartman EMJ, Jin Z, Albaghdadi M, Lu M, Wentzel JJ, Hoffmann U. Physiology and coronary artery disease: emerging insights from computed tomography imaging based computational modeling. Int J Cardiovasc Imaging. 2020 Aug 10. PMID: 32779078.

18. Garcia S, Stanberry L, Schmidt C, Sharkey S, Megaly M, Albaghdadi MS, Meraj PM, Garberich R, Jaffer FA, Stefanescu Schmidt AC, Dixon SR, Rade JJ, Smith T, Tannenbaum M, Chambers J, Aguirre F, Huang PP, Kumbhani DJ, Koshy T, Feldman DN, Giri J, Kaul P, Thompson C, Khalili H, Maini B, Nayak KR, Cohen MG, Bangalore S, Shah B, Henry TD. Impact of COVID-19 pandemic on STEMI care: An expanded analysis from the United States. Catheter Cardiovasc Interv. 2020 Aug 07. PMID: 32767652.

19. Aguilar-Pineda JA, Albaghdadi M, Jiang W, Lopez KJV, Del-Carpio GD, Valdez BG, Lindsay ME, Malhotra R, Lino Cardenas CL. Structural and functional analysis of female sex hormones against SARS-Cov2 cell entry. bioRxiv. 2020 Jul 29. PMID: 32766583.

20. Osborne MT, Abbasi TA, Albaghdadi MS. Narrowing in on a PET tracer that characterizes coronary atheroma: 18F-NaF uptake is increased in stenotic coronary artery disease. J Nucl Cardiol. 2020 Jul 22. PMID: 32699988.

21. Chowdhury MM, Singh KP, Albaghdadi M, Khraishah H, Mauskapf A, Kessinger CW, Osborn EA, Kellnberger S, Piao Z, Lino Cardenas C, Grau MS, Jaff MR, Rosenfield K, Libby P, Edelman ER, Lindsay ME, Tearney GJ, Jaffer FA. The Role of Paclitaxel-Coated Balloon Angioplasty in Atherosclerotic Disease Progression: Assessment by Intravascular Fluorescence Imaging.J Am Coll Cardiol Basic Trans Science. 2020 Jun 10. Epublished DOI:10.1016/j.jacbts.2020.04.007

22. Chowdhury MM, Tarkin JM, Albaghdadi MS, Evans NR, Le EPV, Berrett TB, Sadat U, Joshi FR, Warburton EA, Buscombe JR, Hayes PD, Dweck MR, Newby DE, Rudd JHF, Coughlin PA. Vascular Positron Emission Tomography and Restenosis in Symptomatic Peripheral Arterial Disease: A Prospective Clinical Study. JACC Cardiovasc Imaging. 2020 Apr; 13(4):1008-1017. PMID: 31202739.

23. Garcia S, Albaghdadi MS, Meraj PM, Schmidt C, Garberich R, Jaffer FA, Dixon S, Rade JJ, Tannenbaum M, Chambers J, Huang PP, Henry TD. Reduction in ST-Segment Elevation Cardiac Catheterization Laboratory Activations in the United States during COVID-19 Pandemic. J Am Coll Cardiol. 2020 Apr 09. PMID: 32283124.

24. Alahmad B, Khraishah H, Shakarchi AF, Albaghdadi M, Rajagopalan S, Koutrakis P, Jaffer FA. Cardiovascular Mortality and Exposure to Heat in an Inherently Hot Region: Implications for Climate Change. Circulation. 2020 Apr 14; 141(15):1271-1273. PMID: 32223316.

25. Jaffer FA, Albaghdadi MS. Clinical OCT-Based Polarization Assessment of Coronary Artery Disease: Bending Light to Reveal Atherosclerosis Pathology. JACC Cardiovasc Imaging. 2019 Dec 18. PMID: 31864992.

26. Albaghdadi MS, Garcia-Polite F, Zani B, Keating J, Melidone R, Spognardi A, Markham P, Tzafriri A. Splenic Artery Denervation: Rationale, Feasibility, and Early Pre-Clinical Experience. 2019 Nov; 213:100-111. PMID: 31415732

27. Mansukhani N, So M, Peters E, Albaghdadi M, Wang Z, Karver M, Laux J, Tsihli N, Stupp S, Kibbe M. Peptide Amphiphile Supramolecular Nanostructures as a Targeted Therapy for Atherosclerosis. Macromol Biosci. 2019 Jun; 19(6):e1900066. PMID: 31066494.

28. Mikhael B, Albaghdadi M, Abtahian F, MacKay C, Secemsky E, Jaff M, Weinberg I. Usefulness of a Computerized Reminder System to Improve Inferior Vena Cava Filter Retrieval and Complications. AmJ Cardiol 2019 Jan 15;123(2):348-353. doi: 10.1016/j.amjcard.2018.09.040.PMID:30424866.

29. Al-Bawardy R, Rosenfield K, Borges J, Young MN, Albaghdadi M, Rosovsky R,Kabrhel C. Extracorporeal membrane oxygenation in acute massive pulmonaryembolism: a case series and review of the literature. Perfusion. 2018 Jul1:267659118786830. doi: 10.1177/0267659118786830. [Epub ahead of print] PubMed PMID: 30009670.

30. Fracassi F, Sugiyama T, Yamamoto E, Ghoshhajra B, Gin A, Albaghdadi M, Lee H, Melnitchouk S, Sundt TM, Jang IK. A combined fractional flow reserve and optical coherence tomography approach to guide coronary artery Mazen S. Albaghdadi, MD bypass grafting: A pilot study. J Thorac Cardiovasc Surg. 2018 Sep; 156 (3):997-1000. doi: 10.1016/j.jtcvs.2018.05.037. Epub 2018 Jun 2. PubMed PMID: 29960717.

31. Albaghdadi MS, Yang J, Brown JH, Mansukhani NA, Ameer GA, Kibbe MR. ATailorable In-Situ Light-Activated Biodegradable Vascular Scaffold. Adv MaterTechnol. 2017 Apr; 2 (4). pii: 1600243. doi: 10.1002/admt.201600243. Epub 2017 Feb 20. PubMed PMID: 29578542.

32. Albaghdadi M, Jaffer FA. Wire-Free and Adenosine-Free Fractional Flow Reserve Derived From the Angiogram: A Promising Future Awaiting Outcomes Data. Circ Cardiovasc Imaging. 2018 Mar; 11(3):e007594. doi: 10.1161/CIRCIMAGING.118.007594. PubMed PMID: 29555837.

33. Albaghdadi MS, Dudzinski DM, Giordano N, Kabrhel C, Ghoshhajra B, Jaff MR,Weinberg I, Baggish A. Cardiopulmonary Exercise Testing in Patients Following Massive and Submassive Pulmonary Embolism. J Am Heart Assoc. 2018 Mar 3;7(5).pii: e006841. doi: 10.1161/JAHA.117.006841. PubMed PMID: 29502109.

34. Ain DL, Albaghdadi M, Giri J, Abtahian F, Jaff MR, Rosenfield K, Roy N,Villavicencio-Theoduloz M, Sundt T, Weinberg I. Extra-corporeal membraneoxygenation and outcomes in massive pulmonary embolism: Two eras at an urbantertiary care hospital. Vasc Med. 2018 Feb; 23(1):60-64. doi:10.1177/1358863X17739697. Epub 2017 Nov 10. PubMed PMID: 29125047.

35. So MM, Mansukhani NA, Peters EB, Albaghdadi MS, Wang Z, Rubert Perez CM, Kibbe MR, Stupp S. Peptide Amphiphile Nanostructures for Targeting of Atherosclerotic Plaque and Drug Delivery. Adv Biosys. Feb 12 2018. doi:10.1002/adbi.201700123.

36. Young MN, Albaghdadi M, Al-Bawardy R, Borges J, Rosenfield K. Treatment of an Acute Limb Due to Inferior Vena Cava Filter Thrombosis. JACC Cardiovasc Interv. 2017 Oct 23; 10(20):e189-e192. doi: 10.1016/j.jcin.2017.06.041. Epub 2017 Sep 27. PubMed PMID: 28964763.

37. Essandoh M, Dalia AA, Albaghdadi M, George B, Stoicea N, Shabsigh M, Rao SV. Perioperative Management of Dual-Antiplatelet Therapy in Patients with New-Generation Drug-Eluting Metallic Stents and Bioresorbable Vascular Scaffolds Undergoing Elective Noncardiac Surgery. J Cardiothorac Vasc Anesth. 2017Oct;31(5):1857-1864. doi: 10.1053/j.jvca.2017.04.046. Epub 2017 Apr 26. Review. PubMed PMID: 28826683.

38 .Albaghdadi M. Global Cardiovascular Health: A Role for the Interventionalist. J Am Coll Cardiol. 2017 May 16; 69(19):2461-2464. doi: 10.1016/j.jacc.2017.04.004. PubMed PMID: 28494984.

39. Albaghdadi MS, Wang Z, Gao Y, Mutharasan RK, Wilkins J. High-DensityLipoprotein Subfractions and Cholesterol Efflux Capacity Are Not Affected bySupervised Exercise but Are Associated with Baseline Interleukin-6 in Patients with Peripheral Artery Disease. Front Cardiovasc Med. 2017 Mar 2;4:9. doi: 10.3389/fcvm.2017.00009. eCollection 2017. PubMed PMID: 28303243.

40. Dalia AA, Bamira D, Albaghdadi M, Essandoh M, Rosenfield K, Dudzinski D.Four-Dimensional Transesophageal Echocardiography-Guided AngioVac Debulking of a Tricuspid Valve Vegetation. J Cardiothorac Vasc Anesth. 2017 Oct; 31(5):1713-1716. doi: 10.1053/j.jvca.2016.11.039. Epub 2016 Dec 2. PubMed PMID: 28215497.

41. Albaghdadi M, Jang IK. Flow and plaque phenotype. Coron Artery Dis. 2016Dec; 27 (8):621-622. PubMed PMID: 27798412.

42. Nath C*, Albaghdadi MS*, Jonnalagadda SR. A Natural Language Processing Tool for Large-Scale Data Extraction from Echocardiography Reports. PLoS One. 2016 Apr 28;11(4):e0153749. doi: 10.1371/journal.pone.0153749. eCollection 2016. PubMed PMID: 27124000. *Shared first authors.

43. Albaghdadi MS, Muse ED. Vulnerable Plaque: Absence of Evidence or Evidence ofAbsence. J Am Coll Cardiol. 2015 Aug 11;66(6):757-8. doi: 10.1016/j.jacc.2015.05.071. PubMed PMID: 26248998.

44. Barker AJ, van Ooij P, Bandi K, Garcia J, Albaghdadi M, McCarthy P, Bonow RO, Carr J, Collins J, Malaisrie SC, Markl M. Viscous energy loss in the presence of abnormal aortic flow. Magn Reson Med. 2014 Sep;72(3):620-8. doi:10.1002/mrm.24962. Epub 2013 Oct 2. PubMed PMID: 24122967.

45. Albaghdadi MS, Popescu A, Davidson CJ, McCarthy PM, Kansal P. Adult cardiac fibroma. J Am Coll Cardiol. 2012 Feb 21;59(8):e15. doi: 10.1016/j.jacc.2011.05.066. PubMed PMID: 22340276.

46. Albaghdadi M, Gheorghiade M, Pitt B. Mineralocorticoid receptor antagonism: therapeutic potential in acute heart failure syndromes. Eur Heart J. 2011 Nov;32(21):2626-33. doi: 10.1093/eurheartj/ehr170. Epub 2011 Jun 14. Review. PubMed PMID: 21672933.

47. Gheorghiade M, Albaghdadi M, Zannad F, Fonarow GC, Böhm M, Gimpelewicz C, Botha J, Moores S, Lewis EF, Rattunde H, Maggioni A; ASTRONAUT investigators and study coordinators. Rationale and design of the multicentre, randomized,double-blind, placebo-controlled Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT). Eur J Heart Fail. 2011 Jan;13(1):100-6. doi: 10.1093/eurjhf/hfq209. Epub 2010 Nov 30. PubMed PMID: 21123186.

48. Albaghdadi M. Baroreflex Control of Long-Term Arterial Pressure. Rev Bras Hipertens vol.14(4): 212-225, 2007.


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